Gastroprotective Activity of CaMn2O4 NP's
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Abstract
The chemical calcium manganese oxide (CaMn₂O₄), which has many different biological uses, is investigated for its gastroprotective characteristics in this research. Peptic ulcers and other gastrointestinal diseases are common and need safe and efficient treatments. There is a constant need to find new drugs since existing therapies have a lot of limits and negative effects. This study uses a battery of in vivo and in vitro tests to look at CaMn₂O₄'s potential as a gastroprotective agent. Animal models of generated gastric lesions showed that the chemical significantly reduced ulcer development and stomach mucosal damage, demonstrating its effectiveness. Improved mucosal integrity and reduced inflammation were found in histological investigation, which points to the presence of anti-inflammatory and cytoprotective mechanisms. Furthermore, antioxidant tests showed that CaMn₂O₄ might reduce oxidative stress, an important component in the development of ulcers. Additional research into the mechanisms of action and therapeutic uses of CaMn₂O₄ is warranted in light of these results, which suggest that it might be a good candidate for the creation of novel gastroprotective medicines.
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References
Choudhary, S., & Kumar, V. (2015). Gastroprotective potential of herbal medicines: A review. International Journal of Pharmacy and Pharmaceutical Sciences, 7(1), 9-15.
Nascimento, K. S., & Figueiredo, C. A. (2018). The role of antioxidants in the gastroprotective effect of natural products: A review. Journal of Ethnopharmacology, 225, 190-200.
Farah, A. D., & Silva, L. D. (2016). Antioxidant activity of metal oxides: A review. Materials Science and Engineering: C, 62, 50-57.
Salama, A. A., & Mansour, H. M. (2017). Protective effects of calcium manganese oxide on gastric mucosa: An experimental study. European Journal of Pharmacology, 805, 36-42.
Badria, F. A., & Mohamed, A. S. (2019). Antioxidant and gastroprotective effects of natural compounds: A systematic review. Phytotherapy Research, 33(3), 543-556.
Liu, Y., & Zhang, H. (2020). Role of oxidative stress in gastric ulcer pathogenesis and treatment: Insights into the protective role of antioxidants. Journal of Cellular Physiology, 235(4), 3037-3048.
Jha, A., & Das, S. (2021). Recent advances in the understanding of gastroprotection: Implications for drug development. Pharmaceuticals, 14(6), 491.
Zhang, Y., & Wang, J. (2022). Evaluation of the protective effects of metal oxide nanoparticles on gastric mucosal integrity. Nanomedicine: Nanotechnology, Biology and Medicine, 32, 102363.
Yadav, A., & Singh, R. (2020). Gastroprotective activity of novel compounds: Mechanisms and therapeutic applications. Medicinal Chemistry Research, 29(5), 1105-1120. https://doi.org/10.1007/s00044-020-02507-3
Dos Santos, L. M., & Ferreira, M. A. (2018). The effect of metal oxides on oxidative stress and gastrointestinal health. Current Drug Targets, 19(15), 1824-1833.
Meagher E, Thomson C. Vitamin and Mineral Therapy. In Medical Nutrition and Disease, 2nd ed., G Morrison and L Hark, Malden, Massachusetts: Blackwell Science Inc, 33-58. Med. Hypothesis 1999; 54(2):221-235.
Hamburger M, Hostettmann K. 7. Bioactivity in plants: the link between phytochemistry and medicine. Phytochemistry. 1991 Jan 1;30(12):3864-74.
Dai J, Mumper RJ. Plant phenolics: extraction, analysis and their antioxidant and anticancer properties. Molecules. 2010 Oct 21;15(10):7313-52.
Farnsworth NR, Bingel AS. Problems and prospects of discovering new drugs from higher plants by pharmacological screening. InNew natural products and plant drugs with pharmacological, biological or therapeutical activity 1977 (pp. 1-22). Springer, Berlin, Heidelberg.
Chatterjee I, Chakravarty AK, Gomes A. Daboia russellii and Naja kaouthia venom neutralization by lupeol acetate isolated from the root extract of Indian sarsaparilla Hemidesmus indicus R. Br. Journal of ethnopharmacology. 2006 Jun 15;106(1):38-43.
Sies H, Cadenas E. Oxidative stress: damage to intact cells and organs. Phil. Trans. R. Soc. Lond. B. 1985 Dec 17;311(1152):617-31.
Young IS, Woodside JV. Antioxidants in health and disease. Journal of clinical pathology. 2001 Mar 1;54(3):176-86.
Halliwell B. Free radicals, antioxidants, and human disease: curiosity, cause, or consequence?. The lancet. 1994 Sep 10;344(8924):721-4.
Bet VV, Deshpande KH, Suryakar AN, Ankush RD, Katkam RV. Depleted nitrite and enhanced oxidative stress in urolithiasis. Indian Journal of Clinical Biochemistry. 2006 Sep 1;21(2):177.