Biological Properties oF Ferula assa-foetida Using Silver Nanoparticles (AgNPs)

Abstract

By synthesising and using silver nanoparticles (AgNPs), this work explores the biological features of Ferula assa-foetida, also known as asafoetida.  Traditional medicine has long acknowledged the antibacterial, antioxidant, and anti-inflammatory properties of F. assa-foetida due to its extensive phytochemical composition.  This study developed silver nanoparticles utilising a green synthesis method that included reducing and stabilising chemicals derived from aqueous F. assa-foetida extracts.  A variety of imaging techniques were used to validate the size, shape, and crystalline structure of the synthesised AgNPs, including ultraviolet-visible (UV-Vis), optical, Fourier-transform infrared (FTIR), scanning electron microscopy (SEM), and X-ray diffraction (XRD). Antimicrobial tests against harmful bacteria and fungus, antioxidant capacity as measured by DPPH radical scavenging activity, and cytotoxicity evaluations on certain cancer cell lines were among the in vitro experiments used to determine the biological effectiveness of these AgNPs.  In a dose-dependent manner, the findings showed that the AgNPs mediated by F. assa-foetida were very effective against microbes, had outstanding antioxidant capabilities, and caused noticeable cell death.  These results indicate that biogenic AgNPs produced from F. assa-foetida extracts have great promise for use in biomedicine, particularly in the creation of nanomedicine-based treatments and natural therapeutic agents.  The exact ways they work and whether or not they are effective in living organisms need further investigation.