DIET-INDUCED OBESITY AND THE EPIGENOME/MICROBIOME'S ROLE IN ENDOCANNABINOID-MEDIATED INFLAMMATION REGULATION

Authors

  • Zhang Jiawei Lincoln University College, Petaling Jaya, Malaysia.
  • Nurul Azmir Bin Amir Hashim Lincoln University College, Petaling Jaya, Malaysia.

Keywords:

Diet-induced obesity, Epigenome/Microbiome's, Endocannabinoid, Inflammation regulation

Abstract

Microbiomes, also known as epigenomes, have a role in metabolic wellness and the inflammation linked to diet-induced obesity (DIO), according to recent research. Within the framework of endocannabinoid-mediated inflammatory control in a mouse model, this research explores the interaction between DIO, the epigenomic landscape, or gut microbiota composition. Researchers set out to induce obesity in C57BL/6J mice and track their weight over time to see how a high-fat diet (HFD) affected them, metabolic parameters, or inflammatory markers. Researchers found changes in DNA methylation patterns linked to obesity using genomic sequencing and epigenetic profiling. These changes were most pronounced in genes that control inflammation and lipid metabolism. At the same time, researchers used 16S rRNA sequencing to examine the gut microbiota, which revealed that the HFD was associated with substantial changes in the variety and composition of microbes. It is worth mentioning that researchers saw a rise in microbial taxa that promotes inflammation, which is linked to higher levels of endogenous cannabinoids. Researchers used pharmacological therapies to modify endocannabinoid signalling and assessed their impact on inflammatory responses & metabolic outcomes to uncover the underlying pathways. Our research indicates that inflammation in DIO is modulated by a combination of the microbiota and the epigenome, which in turn affect endocannabinoid signalling. This work emphasises the intricate relationships among nutrition, microbiome, and epigenetic pathways in metabolic health and the possibility of focusing on these pathways as treatment approaches for inflammation associated with obesity. The precise processes at work and their consequences for the treatment and prevention of obesity need more investigation.

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Published

2025-03-02