BIOLOGICAL PROPERTIES oF Fe1.7Cr0.3O3 NANOPARTICLES

Abstract

Innovative methods for synthesizing nanoparticles have surfaced, offering eco-friendly, cost-effective, and biocompatible options to tackle the problem of drug resistance in microbes. The antibacterial efficacy against Fe1.7Cr 0.3O3 NPs, an opportunistic multidrug-resistant (MDR) pathogen, has not been investigated despite the recent introduction of using as a green source to manufacture Fe1.7Cr 0.3O3 NPs. Thus, in order to synthesize Fe1.7Cr 0.3O3 NPs, this work used a reducing and capping agent. The antibacterial, antioxidant, along with anti-inflammatory capabilities of the nanoparticles were evaluated after their characterisation. At 350 nm, the study using UV-Vis spectroscopy showed that there was an absorption band associated with the SPR peak. The crystalline structure of the Fe1.7Cr 0.3O3 NPs was verified by XRD analysis, this further established that 36.2 nm was the size of the crystal. The nanoparticles' iron and oxygen compositions were determined using electron dispersive X-ray spectroscopy. After additional trace elements (<1 ppm) and sodium (1.49 ppm) have been added, the ICP-MS results showed that iron had the greatest concentration at 87.15 ppm. The VSM study showed that the Fe1.7Cr0.3O3 NPs have modest magnetic characteristics. Electron microscopy (SEM) indicated the non-uniform spherical shape and size range of 100-150 nm for the Fe1.7Cr0.3O3 NPs. Thirty clinically isolated forms of Fe1.7Cr0.3O3 NPs were tested for antibacterial activity of Fe1.7Cr0.3O3 NPs, with a maximum inhibition zone of 10 mm. Thirty µg/mL was the MIC measurement for Fe1.7Cr0.3O3 NPs. Nevertheless, no antibacterial effect was seen when Fe1.7Cr0.3O3 NPs were mixed with three chosen antibiotics. Significant anti-inflammatory (IC50 = 70 µg/mL) and antioxidant (IC50 = 22 µg/mL) effects of Fe1.7Cr0.3O3 NPs were seen at different doses when compared to the standard. Fe1.7Cr0.3O3 NPs production might be investigated for potential biological uses and could replace conventional antibacterial medications.